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Post by keppelbay on Feb 7, 2024 14:19:40 GMT
I've commented before on the potential risk for older folks of using GLP1 drugs. My concern was triggered by reports of significant muscle loss, along with the fat loss. And, importantly, that people tended to regain the fat but not the muscle when they went off the drug. Age-related muscle loss is a serious issue for older people. So you can imagine where this leads...
If any of you are considering using Ozempic or other treatments to lose weight, please read this:
What I learned from this article, was that weight loss by normal dieting is associated with significant muscle loss as well as bone loss. This should have been obvious, but I hadn't thought about it that way before.
The main message: if you want to lose weight, do it along with excercise to maintain muscle and bone strength, especially if you are what we might call middle-aged+.
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Post by steelpony10 on Feb 7, 2024 15:09:29 GMT
keppelbay , Those products would be a choice if I was diabetic. That is the reason those products were developed. I watch what I eat to a point, exercise 3-4 times a week at a gym what I consider moderately (strength training and cardio walking up hill). Other genetic conditions are slowly getting to me. Old age is like the Alamo. You lose but some fight harder. It may be a fad using a product off label until someone “famous” suffers serious consequences. But a heart attack or stroke instead may not be a better choice. So a bunch of poor choices including laziness with some unknowns thrown in. Same as most decisions since few have clearcut answers, you take your chances.
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Post by keppelbay on Feb 7, 2024 15:26:57 GMT
The attractiveness of an 'easy fix' to excess weight may lead people to take a risk they don't fully understand. Not an issue for those, like you, who get regular exercise. From an earlier thread, there are a lot of folks here who are very active.
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Post by win1177 on Feb 7, 2024 15:42:15 GMT
I finally went on one of these drugs for my diabetes, at the urging of my cardiologist and primary care MD. On Ozempic, wound up losing about 12-15 pounds, but I was already close to my ideal body weight, 6’3”, 200 lbs. before Ozempic. Now I’m running in mid to high 180’s every day, on the Ozempic. In studies, it has shown benefits as far as cardiac protection in diabetes, and I’ve had Type II AODM since around age 48-50. But I have kept my A1C in “non-diabetic” range by compulsive exercise, watching my diet, etc. My A1C has always been in the 5.2-5.5 range, even before the GLP-1 drug.
So far, I’ve tolerated the medicine fairly well for over a year. A little bit of GI problems, but adapting to them. I do NOT use it for “weight loss”, it’s for cardiac protection due to my AODM. If anything, I’d like to gain a little weight,, my wife is always pissed that I burn calories off, when she struggles trying to lose weight. One problem with it is the pharmacy has trouble stocking it, as so many people are using it for weight loss.
Win
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Post by rhythmmethod on Feb 7, 2024 15:53:05 GMT
Stay healthy, Win!!
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Post by keppelbay on Feb 7, 2024 16:00:06 GMT
win1177, clearly, you have a good reason to be on it, and are using it wisely.
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Post by win1177 on Feb 7, 2024 16:07:57 GMT
win1177 , clearly, you have a good reason to be on it, and are using it wisely. Thanks! It is frustrating when I have to delay the weekly shot for a day or three, because the pharmacy doesn’t have it in stock, due to so much use of it for “weight loss”. I wish the pharmacy would “prioritize” people on it for diabetes, but apparently they don’t. Thought about buying Novo Nordisk, but it’s already really “expensive”, so just watching. Win
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Post by chang on Feb 7, 2024 20:08:25 GMT
Thought about buying Novo Nordisk, but it’s already really “expensive”, so just watching. Win I hate to brag, but normally my timing sucks so badly, I just don't get many opportunities: I bought Novo-Nordisk in August 2022. Posted the trade here: big-bang-investors.proboards.com/post/23151/threadFYI, it was one of my least conviction buys. (I actually bought a chunky amount, and for a while afterward I was wavering with regrets, but just held on.) My higher conviction buys (Nestle, Roche) have done more poorly.
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Post by bizman on Feb 7, 2024 21:58:56 GMT
Congrats, win1177 , on your management of your health. I also have Type 2 diabetes and have been taking Ozempic since about 2018 for it. This was before the talk of weight loss and celebrities taking it off label. My A1C has been well below 7% and am doing well on other health markers since being on it. The stupid thing is that I noticed I was losing weight gradually without really trying, but I never made a point of paying attention to it or how much it was. Esp. with the pandemic and all of that kind of stuff I zoned out on it. Once we came out of the pandemic and I reassembled with family members, there were lots of comments on how much weight I had lost. I figured it out that I lost about 20% of my body weight. Of course, NVO and LLY were then in the stratosphere, and we were soon hearing about the weight loss craze in Hollywood. Thought I had missed it and the stocks have continued higher from there. Amazing how I could be so blind to that opportunity and miss it. Which is why I have way dialed back my individual stock exposure. I will only pick my spots going forward with high conviction ideas, if I find them. One is MSFT, despite its lack of cheapness. The rest of my portfolio is in fairly broadly diversified ETFs. Diabetes doctor recommended I switch from Ozempic to Mounjaro, as effect and weight loss were likely to be somewhat greater in his opinion. So I'm transitioning from one to the other at present. I read an article in Nature Magazine talking about how apparently these GLP-1 drugs reduce inflammation throughout the body including in the brain, which has some optimistic they could even be effective in things like Alzheimer's and Parkinson's. Let's hope! Obesity drugs have another superpower: taming inflammation
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Post by yogibearbull on Mar 7, 2024 15:25:15 GMT
After the cow jumps over the moon, which planet comes next? I thought about this on the news that NVO jumped up this morning.
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